Salicylate Intoxication

Abstract

Salicylates are the most common toxic agent in childhood poisoning. Rapidly absorbed from the gastrointestinal tract, they cause local gastrointestinal irritation, stimulate the respiratory center, increase the metabolic rate, and interfere with carbohydrate metabolism and normal blood coagulation mechanisms. Treatment must prevent further salicylate absorption, correct water and solute deficits, and reduce serum and tissue salicylate levels.