Peripheral Neuropathy as a Sign of Systemic Disease

Abstract

Peripheral motor or sensory disturbances are seen in a wide range of systemic diseases. In the United States the most common of these is diabetes mellitus. The possibility of accidental or intentional poisoning should be considered. Clinical features may be clues to these or other disease states including collagen disease, an infectious process, nutritional deficiency, malignancy, blood dyscrasia, or rare familial disease. A guide to a systematic investigation is presented.