Pathophysiology and Management of Septic Shock

Abstract

Septic shock occurs in about four of every 10 cases of Gram-negative bacteremia. Treatment must be prompt and aggressive and is directed toward assuring a clear airway and efficient pulmonary gas exchange, restoring adequate blood perfusion of vital tissues, and eradicating the infection. Aggressive fluid therapy given early may reverse the shock state. Cautious use of isoproterenol may be beneficial. As the initial antimicrobial agent, gentamicin has been shown to be superior. Use of phenoxybenzamine with fluid loading is still largely investigative.