Drug Therapy in the Aged

Abstract

Drug therapy in the elderly has special hazards because of the anatomic, physiologic and biochemical changes that accompany aging. Digitalis is a common cause of toxic effects, and concomitant administration of a diuretic increases this hazard. Other drugs that should be used with caution include antihypertensives; antibiotics; sedatives, tranquilizers and hypnotics; antidepressants; and analgesics. The best ways to minimize adverse drug reactions in the elderly are to tailor dosage to the individual and to carefully monitor response.