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Abstract
The first approach to analysis of the inheritance pattern of mendelian diseases depends on whether the mutant gene or genes are located on one of the 44 (22 pairs) autosomes or on the one or two X chromosomes. No human disease is known to be associated with a mutant gene on the Y chromosome. In the autosomaldominant inheritance pattern, a mutant gene is inherited from one parent; in the autosomal-recessive pattern, it is inherited from each parent.