Managing chronic leukemias

Abstract

Chronic lymphocytic leukemia and chronic granulocytic leukemia vary considerably in their clinical features, laboratory findings, and therapy, but both generally have an ominous prognosis. Chemotherapy remains the mainstay of treatment in both disorders, with adjunctive measures to control complications such as anemia and splenomegaly. Immunotherapy for granulocytic leukemia is still under study but appears promising.