Abstract
Accumulating evidence suggests that the long-term complications of diabetes mellitus are a result of abnormal metabolism involving lipids and proteins as well as carbohydrates and several hormonal systems. Methods for correction of the abnormalities do not presently exist, but the potential for their future development is great. An understanding of pathogenesis and metabolism is the key to effective therapy, providing the rationale for pharmacologic and nonpharmacologic approaches to diabetes management.