Systemic lupus erythematosus

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Systemic lupus erythematosus (SLE) is a “complicated disorder of unknown etiology.” Given its life-threatening potential and lesser but nevertheless harsh consequences, SLE warrants early diagnosis and appropriately aggressive treatment. In this article, Dr Searles discusses the latest diagnostic criteria and therapeutic approaches to minor and major disease activity in SLE, adding well-deserved cautions about the risks inherent in long-term corticosteroid and immunosuppressive therapy.