Chronic renal failure

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Advances in understanding of the pathophysiology of chronic renal failure have led to better detection and treatment of disease early in its course. Dr Eknoyan succinctly describes the pivotal role of the nonspecialist in this disease and provides therapeutic guidelines for ameliorating symptoms and forestalling end-stage disease. As one reviewer, who enthusiastically endorsed this article, stated, “The author puts the responsibility for recognition and treatment of early disease where it belongs—with the primary care physician—and gives lots of advice on how to do it.”