Prostaglandins in peptic ulcer disease

Preview

The exact pathogenesis of peptic ulcer disease has not been established. However, an imbalance between the secretion of hydrochloric acid and of pepsin and the ability of the gastroduodenal mucosa to resist damage is the basic pathway. Prostaglandins have important effects on factors that can cause imbalance, such as secretion of gastric acid, bicarbonate, and mucus; synthesis of mucus; and regeneration of mucosal cells after injury. Dr Wilson reviews the research and summarizes the current thinking on the relationship between prostaglandins and these and other elements.