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The neurofibromatoses include at least two separate genetic disorders (NF-1 and NF-2) that lead to the formation of tumors surrounding nerves and a variety of other pathologic features. Ongoing investigations into the molecular genetics of these disorders are providing insights that may lead to an understanding of their pathogenesis. The clinical care of affected persons requires recognition of the condition and cognizance of the wide range of potential complications. Dr Korf describes clinical signs of the two types of neurofibromatosis and typical complications associated with them.