Refractory peptic lesions

Preview

Generally, ulcers and erosive reflux esophagitis heal after a couple months of therapy with agents that inhibit gastric acid secretion and bolster mucosal defense mechanisms. Dr Netchvolodoff summarizes the approach to therapy when such healing does not take place. It includes use of high-dose regimens, use of a stronger agent or one with a different mechanism of action, triple-drug therapy for concomitant Helicobacter pylori infection, and surgery when necessary. Evidence from the literature supporting the effectiveness of these techniques is provided.