Hematologic emergencies

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While recognizing that prevention of an acute hemolytic transfusion reaction is the first priority, the authors of this article review the common manifestations of this unfortunate event and discuss emergency measures for treatment. They also examine the management of major crises in sickle cell disease, including debilitating pain, stroke, and priapism. A companion article on page 193 addresses the problems of the hyperleukocytic syndrome, disseminated intravascular coagulopathy, and thrombotic thrombocytopenic purpura.