Lipoproteins and apolipoproteins

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Plasma contains four major lipoprotein particles: chylomicrons, VLDLs, LDLs, and HDLs. How cholesterol is metabolized depends on the particle with which it is associated. Thus, treatment for hypercholesterolemia is most effective when it is designed to fit the lipoprotein features of a given patient. Dr Kottke describes the five common forms of hyperlipoproteinemia and provides specific therapeutic approaches for each.

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Notes on contributors

Bruce A. Kottke

Bruce A. Kottke, MD, PhD Dr Kottke is in private practice specializing in vascular diseases and lipidology, Watson Clinic, Lakeland, Florida. His major Interests currently include the development of methods for quantitating complex lipoprotein particles and for measuring platelet activation and applying these measurements in preventive cardiology and vascular disorders.