Systemic lupus erythematosus

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Although systemic lupus erythematosus affects primarily young and middle-aged women, a percentage of cases occur in all age-groups and both sexes. That fact, coupled with the diversity of clinical presentations, can make diagnosis a challenge. This article discusses epidemiologic and pathogenetic factors and describes the many manifestations of the disease. A brief overview of current treatment is presented.

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Notes on contributors

Joan M. Von Feldt

Joan M. Von Feldt MD Dr Von Feldt is assistant professor of medicine, division of rheumatology, University of Pennsylvania School of Medicine, Philadelphia. Her area of research includes neuropsychiatric manifestations of systemic lupus erythematosus, especially cognitive deficits.