Association between sedentary behavior and normal-range lactate dehydrogenase activity

ABSTRACT

Objectives: Recent research demonstrates that lactate dehydrogenase (LDH) activity within the normal range may serve as a mediator in the (positive) relationship between physical activity and cardiovascular disease risk. Emerging work supports deleterious associations between sedentary behavior and health, independent of physical activity. Thus, this study evaluated if sedentary behavior was associated with normal-range LDH activity, independent of physical activity.

Methods: Data from the 2003–2006 NHANES were used (N = 2,087 adults; 40–79 yrs). LDH activity levels were estimated from a blood sample using LX20 and LDH reagent; participants were included if they had LDH activity levels within the normal range (105–333 IU/L). Physical activity and sedentary behavior were assessed via accelerometry.

Results: Sedentary behavior was inversely associated with normal-range LDH activity when physical activity was excluded from the model (OR = 0.89; 95% CI: 0.83–0.97, P = 0.009 for LDH activity quartile 4 vs. 1). However, sedentary behavior was no longer associated with normal-range LDH activity after controlling for physical activity and other covariates (OR = 1.00, P = 0.49 for LDH activity quartile 2 vs. 1; OR = 1.00, P = 0.72 for LDH quartile 3 vs. 1; and OR = 0.99, P = 0.36 for LDH quartile 4 vs. 1).

Conclusion: Unlike physical activity, sedentary behavior is not independently associated with normal-range LDH activity.

KEYWORDS:

• Accelerometry
• epidemiology
• NHANES

Declaration of interest

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties

Additional information

Funding

This article was not funded.