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ABSTRACT
Objective
This study aimed to analyze the characteristics of platelet-associated parameters in nonalcoholic fatty liver disease (NAFLD) patients with varying degrees of disease severity and investigate the sexual dimorphism of platelet features in NAFLD patients.
Methods
A total of 829 NAFLD patients were divided into separate groups based on body mass index (BMI), liver stiffness measurement (LSM), controlled attenuation parameter (CAP), and alanine aminotransferase (ALT) levels. The platelet count (PC), mean platelet volume (MPV), and platelet distribution width (PDW) parameters were analyzed among different groups, and the sex-based differences were compared.
Results
The PC decreased with age in both sexes; in 30–59-year-old female subjects, the PC decreased by a conspicuous margin. The MPV increased with age in females, but not in males. The PDW increased significantly in females aged 30–59 years. With the increase in BMI and CAP, the PC showed a decreasing trend. The MPV increased with the increasing CAP value in male patients. With the increasing LSM value, the PC displayed a decreasing trend.
Conclusion
The PC showed marked sex-based differences in NAFLD patients and is affected by age and BMI. Regular changes of platelet parameters could be found in patients with varying degrees of NAFLD. These changes might be helpful in assessing the severity of NAFLD.
Ethics approval and consent to participate
The study was approved by the Ethics Committee of China-Japan Union Hospital of Jilin University (permission number: 2016ks009).
Declaration of interest
The authors declare that they have no financial and non-financial competing interests.
List of abbreviation
| NAFLD | = | nonalcoholic fatty liver disease |
| PLT | = | Platelet |
| PC | = | Platelet Count |
| MPV | = | Mean platelet volume |
| PDW | = | Platelet distribution width |
| LSM | = | Liver stiffness measurement |
| CAP | = | controlled attenuation parameter |
| BMI | = | body mass index |
| ALT | = | Alanine aminotransferase |
| AST | = | Aspartate aminotransferase |
| GGT | = | γ-glutamyl transpeptadase |
| ALP | = | alkaline phosphatase |
| ALB | = | albumin |
| TG | = | triglycerides |
| CHOL | = | - cholesterol |
| LDL-C | = | Low-density lipoprotein cholesterol |
| HDL-C | = | high-density lipoprotein cholesterol |
| Glu | = | glucose |
| UA | = | uric acid |