Post-hospital discharge venous thromboembolism prophylaxis in medically ill patients

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ABSTRACT

There is a widely expressed concern about an unmet need for post hospitalization venous thromboembolism (VTE) prophylaxis in medically ill patients, however, physicians and hospitals have been slow to implement this measure. Recommendations against extended VTE prophylaxis in medical patients from the American Society of Hematology (ASH) in 2018 and the withholding of approval of betrixiban by the European Medicines Agency also in 2018 may have been influential in this regard. Furthermore, rivaroxaban the other drug approved for this indication in the U.S has not yet been approved in Europe. In addition, hospital administrators, those monitoring expenses in the U.S, have been reluctant to support a treatment which will mostly involve outpatients. Internal medicine physicians, hospitalists and nursing home physicians have not shared the fervor for post hospital VTE prophylaxis, whether with anticoagulants or aspirin, that their orthopedic surgery colleagues have, particularly in hip and knee arthroplasty. This is despite an increased risk of post hospital discharge thrombosis in both groups of patients. Enter hospitalized patients with COVID-19, a potentially severe medical illness with high hospitalization related thrombosis risk, and questions arise as to whether these medical patients, who are clearly more hypercoagulable during hospitalization than those in previous studies, should warrant post hospital discharge prophylaxis.

KEYWORDS:

• Apex
• magellan Mariner
• venous thrombosis
• prophylaxis
• anticoagulation
• hospital discharge

Declaration of financial/other relationships

SB is a speaker for Janssen pharmaceuticals and Alexion pharmaceuticals.

A reviewer on this manuscript has disclosed that they have previously received an investigator-initiated research grant and travel grant from Sanofi (manufacturer of enoxaparin). Peer reviewers on this manuscript have no other relevant financial relationships or otherwise to disclose.

Acknowledgments

None stated.

Declaration of interest

No potential conflict of interest was reported by the author.

Additional information

Funding

No funding was received to produce this article.