https://orcid.org/0000-0002-5881-1565
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ABSTRACT
Aim
The most serious form of urinary tract infection (UTI) is acute pyelonephritis (APN), which can result in bacteremia and renal scarring. This study aims to show the roles that the systemic immune-inflammation index (SII) and the immature granulocyte (IG) percentage play in predicting APN in pediatric patients by comparing them with traditional infection markers. By illustrating a significant relationship between APN, the IG percentage, and the SII, the study’s contributions to the differential diagnosis of UTI can promote a rapid and appropriate treatment of APN.
Material and Methods
The present study included 522 pediatric patients. The patients were divided into two groups: (I) an APN group (n = 236) and (II) a lower UTI group (n = 286).
Results
The mean age of the sample was 5.05 ± 4.7 years. According to the most appropriate cutoff values, the findings showed that among all the parameters, C-reactive protein (CRP) and the IG percentage had the highest sensitivities, specificities, and predictive values for predicting APN.
Conclusion
This study emphasizes the support features of the IG percentage and the SII in the diagnosis of APN in pediatric patients, a topic that has recently attracted attention. The findings indicated that among all of the parameters behind CRP, the IG percentage and the SII had the highest sensitivities, specificities, and predictive values for forecasting APN. It is worth noting that these methods can be applied without additional costs or burdens to the patient.
Acknowledgments
The authors gratefully acknowledge Scribendi (www.scribendi.com) for English language editing.
Declaration of financial
No potential conflict of interest was reported by the author.
Reviewer disclosures
Peer reviewers on this manuscript have no relevant financial or other relationships to disclose.