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Abstract
Subunits of α2 macroglobulin (α2M) with sedimentation rates lower than 10 S were found in ultrafiltrates (through macroglobulin-stopping membranes) of normal human sera. Five to six percent of the total α2M in human sera exists in subunit form. After isolation by means of ammonium sulfate precipitation, curtain electrophoresis, gel filtration and ultrafiltration these subunits were shown to have sedimentation rates of 5–10 S.