Circulating endothelial and endothelial progenitor cells in microvascular repairs in pancreatic hyperglycaemic-induced damage: a review

Abstract

The body vasculature contains an inner lining of endothelium, which consists of highly metabolic active endothelial cells (ECs). In microvascular damage resulting from the detrimental physiological effects of hyperglycaemia, ECs are unable to change their glucose transport rate. This results in the mobilisation and recruitment of endothelial progenitor cells (EPCs) to the site of injury for neovascularisation and vascular repair. This review assessed the implications of circulating endothelial and endothelial progenitor cells (CEPCs) on pancreatic microvascular repair and highlighted the impact of EPCs in neovascularisation. This insight information may open up new avenues of research on novel approaches to maintaining and regenerating microvasculature in diabetes mellitus.

Keywords:

• CEC
• CEPC
• diabetes mellitus
• hyperglycaemia
• vascular repair

ORCID

Venant Tchokonte-Nana http://orcid.org/0000-0003-2240-3735