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Original Article

Experimental pathology of Aspergillus terreus-flavipes group species

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Pages 89-93 | Published online: 09 Jul 2009
 

Abstract

The aleuriospore, a secondary submerged spore type found in the Aspergillus terreus-flavipes group, was recently shown to have taxonomic significance as well as a unique morphology. Aleuriospores were demonstrated in pathological material from a pulmonary aspergilloma. In a series of experiments, mice were inoculated intravenously with A. carneus, A. flanipes, A. niveus and A. terreus. Although there was species and strain variation in virulence, all species caused lateral and truncal ataxia which was frequently correlated with multiple acute aspergillomas of the cerebellum and cerebrum. All 4 species produced aleuriospores in brain tissue, which was diagnostic for the group, in contrast to other Aspergillus spp. which did not. The aleuriospores were identical in morphology to those produced in vitro and represent a rare example of exogenous sporulation by fungi in non-necrosed tissues.

Zusammenfassung

Die Aleuriospore, ein sekundärer Typ von Submerssporen, der in der Aspergillus terreus-flavipes-Gruppe gefunden wurde, hat, wie jüngst nachgewiesen, taxonomische Bedeutung und eine einzigartige Morphologie. Aleuriosporen wurden im pathologischen Material einer Lungenaspergilloms dargestellt. Mäuse wurden in einer Reihe von Versuchen intravenös mit A. carneus, A. flavipes, A. niveus und A. terreus geimpft. Obwhol die Virulenz bei den einzelnen Arten und Stämmen variierte, verursachten alle Species laterale und Stamm-Alaxien, die häufig mit multiplen akuten Aspergillombildungen im Hirn und Kleinhirn einhergingen. Alle vier Species bildeten—im Gegensatz zu anderen Aspergillus-Arten-im Hirngewebe Aleuriosporen, ein diagnostisches Gruppenmerkmal. Die Aleuriosporen waren in ihrer Morphologie identisch mit solchen in vitro und stellen ein seltenes Beispiel von exogener Pilzsporen bildung in nicht nekrotischem Gewebe dar.

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