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Original Article

Immunological relationships between glycopeptides of Microsporum canis, Trichophyton rubrum, Trichophyton mentagrophytes and other fungi

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Pages 119-126 | Published online: 09 Jul 2009
 

Abstract

Allergenic glycopeptides have been extracted from cultures of Trichophyton mentagrophytes, T. rubrum, T. schoenleinii, Microsporum canis, Keratinomyces ajelloi and Epidermophyton floccosum. These have very similar chemical structures and all give rise to both immediate and delayed hypersensitivity reactions in sensitised guinea pigs. A range of polysaccharides from other sources was tested in guinea pigs sensitised to dermatophytes. None gave delayed reactions, but some with structural features in common with those isolated from dermatophytes gave immediate reactions.

Zusammenfassung

Allergenische Glycopeptide wurden aus Kulturen von Trichophyton mentagrophytes, T. rubrum, T. schoenleinii, Microsporum canis, Keratinomyces ajelloi und Epidermophyton floccosum extrahiert. Diese haben sehr ähnliche chemische Strukturen und bewirken alle bei sensibilisierten Meerschweinchen Ueberempfindlichkeitsreaktionen vom Sofort-und Spättyp. Eine Anzahl von Polysacchariden anderer Herkunft wurde an Meerschweinchen geprüft, die gegen Dermatophyten sensibilisiert waren. Keines führte zu Spätreaktionen, aber einige Proben mit gleichen Struktureigenschaften wie Material aus Dermatophyten bewirkten Sofortreaktionen.

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