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Original Article

Effect of cortisone on bronchopulmonary aspergillosis in mice exposed to spores of various Aspergillus species

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Pages 32-38 | Published online: 09 Jul 2009
 

Abstract

The effect of cortisone on bronchopulmonary aspergillosis in experimental mice forced to inhale aerosols of dry and viable spores of 6 Aspergillus species was investigated. A significant enhancement in mortality and tissue invasion due to all the test species: — A. flavus, A. fumigatus, A. nidulans, A. nidulans var. dentatus, A. niger, A. tamarii and A. terreus was observed in the cortisone treated animals.

Zusammenfassung

Bei Mäusen wurden bronchopulmonale Aspergillosen mit Aspergillus flavus, A. fumigatus, A. nidulans, A. nidulans var. dentatus, A. niger, A. tamarii und A. terreus erzeugt, indem die Tiere zur Inhalation trockener Sporen-Aerosole gezwungen wurden. Verabreichung von Cortison führte bei allen Infektionen zu signifikant vermehrter Mortalität der Tiere und zu tieferem Eindringen der Pilze ins Gewebe.

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