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Original Article

In vitro susceptibility of Cryptococcus neoformans to steroids

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Pages 171-172 | Published online: 09 Jul 2009
 

Abstract

The inhibitory effect of estradiol, norethynodrel, progesterone, testosterone and diethylstilbestrol on 7 human isolates of C. neoformans was determined. Northynodrel, progesterone or testosterone had no apparent effect on their growth. Diethylstilhestrol at a concentration of 10 μg/ml completely suppressed the growth of all isolates and estradiol at a concentration of 1·0 μg/ml completely suppressed the growth of 3 isolates and moderately inhibited the remainder.

Zusammenfassung

Der hemmende Effekt von Oestradiol, Noräthynodrel, Progesteron, Testosteron und Diäthylstilböstrol auf sieben vom Menschen isolierte Stämme eines Cryptococcus neoformans wurde bestimmt. Noräthynodrel, Progesteron, oder Testosteron hatten keinen nachweisbaren Effekt auf das Wachstum von C. neoformans. Diäthylstiböstrol in einer Konzentration von 10 μg/ml unterdrukte vollkommen das Wachstum aller Stämme. Oestradiol in einer Konzentration von 1·0 μg/ml verhinderte jegliches Wachstum von 3 Stämmen und hemmte mässig das Wachstum der restlichen 4 Stämme.

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