Abstract
Reported is a short term (16 week) experiment to determine the distribution of B. dermatitidis in dogs when infected by the natural inhalation route by receiving about 250,000 viable particles during a 24h. exposure. Four dogs were positive to blastomycin and 1 to histoplasmin prior to exposure. Post exposure, all dogs developed positive skin tests to blastomycin by the 4th week with considerable cross reaction to histoplasmin. Serologic tests showed more positive CF tests to Histoplasma than to Blastomyces so that the test appears of no practical value. Although 22 tissues were cultured on each dog, only 1 of 7 dogs was positive for B. dermatitidis by 2 weeks. At 4 weeks, 57% of the dogs were positive by culture and at 12, 15, and 16 weeks, all were positive. One dog developed eye lesions and became emaciated.
Resume
On étudie la distribution de Blastomyces dermatitidis chez des chiens expérimentalement infectés par inhalation. Pré-exposition, 4 chiens sont positifs à la blastomycine et 1 à l'histoplasmine; post-exposition, tous sont positifs à la blastomycine dans les 4 semaines avec une réaction croisée considérable à la l'histoplasmine. Les tests de réaction du complément sont plus positifs à l'Histoplasma qu'aux Blastomyces. Un chien sur 7 donne des cultures positives après 2 semaines; 4 sur 7 après 4 semaines et tous les chiens inoculés après 12 semaines et plus. Un chien a développé des lésions oculaires et est devenu émacié.