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Original Article

Immunoglobulin classes of antibodies to Aspergillus fumigatus in patients with pulmonary aspergillosis

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Pages 204-208 | Published online: 09 Jul 2009
 

Abstract

An indirect immunofluorescence test was used to determine the titre and immunoglobulin classes of antibodies to Aspergillus fumigatus in human serum. In 15 patients with aspergillosis, significant titres of IgG but not IgA or IgM antibodies were found. The IgG, IgA and IgM fractions of serum from 2 patients with aspergillosis were separated. This confirmed that antibodies to A. fumigatus reside in highest titre in the IgG fraction. Precipitating antibodies to A. fumigatus in these patients also belonged to the IgG class of immunoglobulin.

Resume

La méthode indirecte d'immunofluorescence est utilisée pour déterminer le titre et les classes d'immunoglobuline des anticorps anti-Aspergillus fumigatus dans le sérum humain. Chez 15 malades atteints d'aspergillose on met en évidence des titres significatifs d'anti-IgG mais non d'anti-IgA ou IgM. Les fractions IgG, IgA et IgM du sérum de 2 malades sont séparées et l'on confirme que les anticorps anti-A. fumigatus sont caractérisés par un titre plus élevé en fraction IgG. Chez ces malades, les anticorps précipitants anti-A. fumigatus appartiennent également aux IgG.

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