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Original Article

Kluyveromyces fragilis as an opportunistic fungal pathogen in man

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Pages 69-73 | Published online: 09 Jul 2009
 

Abstract

An immunosuppressed cardiac transplant patient with pulmonary infection due to the yeast Kluyveromyces fragilis is described. Isolation of this fungus from human sources is rarely reported, and previous reports of human infection are unavailable in the modern literature. The organism is poorly pathogenic even in immunocompromised hosts. In vitro susceptibility studies with several strains presented here indicate inhibition by 5-fluorocytosine and miconazole, and borderline susceptibility to amphotericin B. The patient was treated with amphotericin B, and recovered without sequelae.

Sumario

Se describe el caso de un paciente inmunosuprimido con transplante cardíaco y en el cual se desarrolló infección pulmonar por la levadura Kluyveromyces fragilis. El aislamiento de este hongo a partir de fuentes humanas es informado solo raramente, no existiendo reportes previos de infección en el hombre en la literatura moderna. El organismo es poco patógeno aún en huéspedes con compromiso del estado inmune. Estudios in vitro sobre la sensibilidad de varias cepas indican inhibición por 5-fluorocitosina y miconazole, con sensibilidad limítrofe a la anfotericina B. El paciente fue tratado con anfotericina B y se recupero sin secuelas.

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