Abstract
The thermotolerant fungi Radiomyces spectabilis and R. embreei were tested for their ability to produce disease when injected intravenously into mice. All three strains of R. embreei tested were able to produce death in normal and cortisone-treated mice. Hyphal invasion was consistently observed in the kidneys of these animals, and involvement of the brain, heart and lungs was often seen at inoculum dosages of 104 and 105 spores. The single strain of R. spectdilis tested did not produce deaths; although cortisone-treated animals sometimes exhibited unilateral kidney involvement at necropsy.
Resúmen
Se estudió la patogenicidad de los hongos termotolerantes Radiomyces spectabilis y R. embreei en ratones inoculados intravenosamente. Las tres cepas de R. embreei examinadas produjeron la muerte en ratones tanto normales como tratados con cortisona. Se observó, consistentemente, la invasion por hifas en los rinones de los animales; inyectando dosis de 104 a 105 esporas se produjo además, compromiso cerebral, cardíaco y pulmonar. La única cepa de R. spectabilis examinada no produjo muertes, algunos de los animales tratados con cortisona mostrarom compromiso renal unilateral en el estudio post mortem.