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Original Article

Trichophyton rubrum and the chemotaxis of polymorphonuclear leucocytes

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Pages 65-71 | Accepted 28 Jun 1983, Published online: 09 Jul 2009
 

Abstract

In experiments with a Boyden-type chamber, both the cell wall and a cytoplasmic extract of Trichophyton rubrum acted as chemotaxigens for polymorphonuclear neutrophils in the production of neutrophil chemotactic factor from plasma. Activation of complement by the cytoplasmic extract to produce neutrophil chemotactic factor is shown to be predominantly through the alternative pathway and the cytoplasmic extract mimics the activity of the complementary system.

Resume

Dans des expériences du type Boyden, la paroi et l'extrait cytoplasmique de Trichophyton rubrum (CeTr) se montrent, l'un et l'autre, chimiotaxigènes pour les polynucléaires neutrophiles (PMN), au fait de la production d'un facteur chimiotactique neutrophile (NCF) à partir du plasma. On a montré que l'activation du complément par le CeTr, lors de la production du NCF, s'effectue principalement par la voie alterne et que le CeTr montre une activité semblable à celle du système complémentaire.

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