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Original Article

IgA and IgG antibodies to Candida albicans in the genital tract secretions of women with or without vaginal candidosis

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Pages 265-271 | Accepted 20 Jan 1984, Published online: 09 Jul 2009
 

Abstract

Levels of anti-Candida albicans immunoglobulin A (IgA) and IgG were measured by enzyme-linked immunosorbent assay in serum and cervicovaginal secretions from 64 non-pregnant women with vaginal candidosis and 158 uninfected non-pregnant women. Specific IgA and IgG were detected in the serum and secretions of all 222 women. There was no significant difference between the mean levels of specific IgA or IgG in secretions from women with candidosis and those of uninfected women. Neither was there a significant difference between mean levels of specific IgA or IgG when women using oral contraception were compared with others who were not. There was a significant correlation between the levels of IgA and IgG in serum and secretions from women with candidosis and from uninfected women. Blastospore and hyphal forms of C. albicans were seen in vaginal smears from 29 of the 64 women with culture-proven candidosis: in nine, both IgA- and IgG-coated C. albicans cells were recovered from the genital tract; in a tenth, IgG-coated cells were found.

Zusammenfassung

Bei 64 nicht schwangeren Frauen mit einer vaginalen Candidose und bei 158 gesunden, nicht schwangeren Frauen werden mittels ELISA im Serum und im Cervix-Vaginalsekret Anti-Candida albicans IgA und IgG Titer bestimmt.

Spezifische IgA und IgG-Antikörper werden bie allen 222 Probanden gefunden. Es ergaben sich keine signifikanten Titerdifferenzen zwischen gesunden Frauen und solchen mit einer vaginalen Candidose. Weiterhin ergaben sich keine Titerunterschiede zwischen einer Gruppe von Frauen, die orale Kontrazeptiva benutzten, und einer Kontrollgruppe. Eine Korrelation der Serumtitel zwischen gesunden Probanden und Frauen mit vaginaler Candidose wurde nicht festgestellt. Bei 29 Patienten mit vaginaler Candidose konnten im Vaginalsekret sowohl Blastosporen als auch Hyphenformen von C. albicans nachgewiesen werden. Bei 9 Patienten konnten IgA und IgG beladene C. albicans Zellen, bei 1 Patienten nur IgG beladene Hefezellen nachgewiesen werden.

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