Biological variation and analytical imprecision of CA 125 in patients with ovarian cancer

M. K. Tuxen Department of Oncology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark and Department of Internal Medicine, Hvidovre Hospital, Hvidovre, Denmark

G. J. S. Rustin Cancer Treatment Centre, Mount Vernon Hospital, Middlesex, UK

P. Dombernowsky Department of Oncology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark

G. Sölétormos Department of Oncology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark and Department of Clinical Biochemistry, Hillerod County Hospital, Hillerod, Denmark

A. E. Nelstrop Cancer Treatment Centre, Mount Vernon Hospital, Middlesex, UK

Abstract

Despite the availability of serial data on CA 125 in ovarian cancer, the problem of interpreting a change over time is still unsolved. Changes in marker concentrations are due not only to patients improving or deteriorating but also to analytical imprecision and normal intra-individual biological variation. The aim of this study was to assess the analytical imprecision (CV_A) and the intraand inter-individual biological variation (CV_I and CV_G

Keywords

Analytical Variation Biological Variation Critical Difference Index Of Individuality Ovarian Cancer Tumor Marker Assessment Criteria

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Biological variation and analytical imprecision of CA 125 in patients with ovarian cancer

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Biological variation and analytical imprecision of CA 125 in patients with ovarian cancer

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