How do conventional markers of lipid disorders compare with apolipoproteins?

Abstract

Assessment of risk for coronary heart disease (CHD) indicates that apolipoprotein B and apolipoprotein A‐I and their ratio are efficient predictors, possibly superior to hitherto used indicators, i.e. S‐Cholesterol, S‐Triglycerides, S‐HDL cholesterol and S‐LDL cholesterol. We used the ratio S‐Apolipoprotein B/S‐Apolipoprotein A‐I as the gold standard to compare the diagnostic performance of the other properties based on consecutive routine measurements in patients attending primary health‐care or a university hospital. The different cut‐offs of the S‐Apolipoprotein B/S‐Apolipoprotein A‐I ratio that were investigated created a prevalence of risk factors that might require intervention in the study group between 10 and 77%. The gender difference prompts for a partitioning related to the gender, whereas the changes related to age were small and were disregarded. The diagnostic sensitivity and specificity were demonstrated in ROC diagrams for the studied properties.

• CHD
• coronary heart disease
• cost analysis
• diagnostic sensitivity
• diagnostic specificity
• risk assessment
• ROC analysis
• scattergrams