Tetranectin in cerebrospinal fluid of patients with multiple sclerosis

Abstract

Objective. Tetranectin (TN) is a glycoprotein and C‐type lectin thought to play a prominent role in tissue remodelling. The aim of this study was to determine the TN serum and cerebrospinal fluid (CSF) concentration in patients with multiple sclerosis (MS) and controls. Material and methods. Two‐hundred‐and‐four patients, divided into four diagnostic groups, i.e. definite MS (n = 76), possible onset symptoms of MS (n = 48), other non‐inflammatory neurological diseases (n = 61) and other inflammatory neurological diseases (n = 19) and 47 controls with no history of neurological disease were analysed for TN in serum and CSF using a polyclonal sandwich ELISA. Results. All tested groups, e.g. definite MS, possible onset symptoms of MS, other neurological disease, both inflammatory and non‐inflammatory, had decreased concentrations of TN in the CSF compared to the concentrations in controls. The quotient of TN in CSF divided by the concentration in serum (QTN) correlated significantly with the same quotient of albumin (QALB), was significantly correlated with the same quotient of albumin QALB. To account for differences in blood brain barrier permeability, we calculated a TN‐index defined as: TN‐index = QTN/QALB. QTN was significantly decreased in all groups compared to that in controls. However, in definite MS and patients with first attack of MS, the TN‐index was not significantly different from that of controls. In contrast, other neurological diseases, both inflammatory and non‐inflammatory, were associated with a decreased TN‐index. Conclusion. These results indicate that TN may play a role in neurological diseases and may serve as a diagnostic aid in MS.

• Intrathecal synthesis
• neurological disease
• TN‐index

Acknowledgements

The skilled technical assistance of Connie Kjellkvist, Jette Rasmussen and Anetta Clausen is acknowledged.