C‐reactive protein, genetically elevated levels and risk of ischemic heart and cerebrovascular disease

Abstract

We tested whether genetically elevated levels of C‐reactive protein (CRP) cause increased risk of ischemic heart disease and ischemic cerebrovascular disease. Levels of CRP >3mg/L, compared with levels <1mg/L, associated with a 1.6‐ and 1.3‐fold increased risk of ischemic heart disease and ischemic cerebrovascular disease. Genotype combinations of the 4 CRP polymorphisms associated with up to a 64% increase in CRP levels, resulting in a theoretically predicted increased risk of up to 32% for ischemic heart disease and up to 25% for ischemic cerebrovascular disease. However, these genotype combinations did not associate with increased risk of ischemic heart and cerebrovascular disease.

• Cardiology
• lipids
• lipoproteins and cardiovascular markers
• high sensitive CRP