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Beta-hydroxybutyrate and pyroglutamate can be included in a rapid GC-MS screening method for differential diagnosis of metabolic acidosis

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Pages 149-152 | Received 02 Sep 2016, Accepted 10 Dec 2016, Published online: 02 Feb 2017
 

Abstract

A rapid gas chromatographic mass spectrometric method for measuring anions associated with acute anion gap metabolic acidosis is described. The method is an extension of a previous method. The method quantifies glycolic acid, beta-hydroxybutyric acid with good linearity and pyroglutamic acid with a reproducible curvature relation between 1 and 20 mmol/L and can help the clinician distinguish effectively between ethylene glycol poisoning, alcoholic and diabetic ketoacidosis and cysteine deficiency so early that it will have clinical consequences.

Disclosure statement

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper. There was no external funding.

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