152
Views
0
CrossRef citations to date
0
Altmetric
Original Article

The soluble transcobalamin receptor (sCD320) in relation to Alzheimer’s disease and cognitive scores

, , &
Pages 332-337 | Received 02 Jun 2016, Accepted 23 Apr 2017, Published online: 09 May 2017
 

Abstract

The soluble transcobalamin receptor (sCD320) is present in cerebrospinal fluid and correlates with the dementia-related biomarkers phospho-tau and total-tau. Here we present data on the relation of sCD320 to Alzheimer’s disease and scores of cognitive tests. Lumbar cerebrospinal fluid samples from 42 pathologically-confirmed cases of Alzheimer’s disease and 25 non-demented controls were analyzed for sCD320 employing an in-house ELISA. The participants’ cognitive functions were tested using the Cambridge Cognition Examination (CAMCOG) and the Mini-Mental State Examination (MMSE). There was no significant difference in the median CSF sCD320 concentration between patients and controls. The median (2.5–97.5 percentiles) sCD320 for all participants (n = 67) was 15 (3–29) pmol/L. We observed a non-linear correlation between sCD320 and cognitive scores. Spearman’s correlation between sCD320 and total CAMCOG scores was 0.627 (n = 16, p = .009) for CAMCOG scores ≤27, and −0.293 (n = 39, p = .071) for CAMCOG scores ≥68. Spearman’s correlation between sCD320 and both the low (≤9) and high (≥16) total MMSE scores was 0.274, −0.363 (n = 18, 44), p = .272, .016, respectively. In conclusion, sCD320 cannot be employed as a biomarker for differentiating Alzheimer dementia patients from controls. Further studies are warranted to explore the non-linear correlations between sCD320 and scores of cognitive function.

Acknowledgements

We warmly appreciate the excellent technical assistance offered by Inger Marie Jensen. This work was supported by Aarhus University Research Foundation (AUFF-F2012-FLS 3-37) and the Lundbeck Foundation.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by Aarhus University Research Foundation (AUFF-F2012-FLS 3-37) and the Lundbeck Foundation.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.