Bariatric surgery reduces fasting total fatty acids and increases n-3 polyunsaturated fatty acids in morbidly obese individuals

Anders HovlandCoronary Care Unit, Division of Internal Medicine, Nordland Hospital, Bodø, Norway; ;Department of Clinical Medicine, University of Tromsø, Tromsø, Norway; Correspondence[email protected]

Torunn NestvoldDepartment of Surgery, Nordland Hospital, Bodø, Norway;

Pavol BohovDepartment of Clinical Science, University of Bergen, Bergen, Norway;

Marius TrøseidSection of Clinical Immunology and Infectious Diseases, Oslo University Hospital, Oslo, Norway; ;Research Institute of Internal Medicine, Oslo, Norway; ;K.G. Jebsen Centre for Inflammation Research, Oslo, Norway; ;Institute of Clinical Medicine, University of Oslo, Oslo, Norway;

Pål AukrustSection of Clinical Immunology and Infectious Diseases, Oslo University Hospital, Oslo, Norway; ;Research Institute of Internal Medicine, Oslo, Norway; ;K.G. Jebsen Centre for Inflammation Research, Oslo, Norway; ;Institute of Clinical Medicine, University of Oslo, Oslo, Norway;

Rolf K. BergeDepartment of Clinical Science, University of Bergen, Bergen, Norway; ;Department of Heart Disease, Haukeland University Hospital, Bergen, Norway;

Erik Waage-NielsenDepartment of Clinical Medicine, University of Tromsø, Tromsø, Norway; ;Department of Anesthesiology, Nordland Hospital, Bodø, Norway; ;University of Nordland, Bodø, Norway;

Kjetil RetterstølDepartment of Nutrition, Institute for Basic Medical Sciences, University of Oslo, Oslo, Norway; ;The Lipid Clinic, Oslo University Hospital Rikshospitalet, Oslo, Norway

Knut Tore LappegårdCoronary Care Unit, Division of Internal Medicine, Nordland Hospital, Bodø, Norway; ;Department of Clinical Medicine, University of Tromsø, Tromsø, Norway;

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Abstract

Background: Obesity is a global pandemic leading to increased mortality and increased risk of cardiovascular disease. Bariatric surgery is an established treatment of obesity leading to weight loss and reduction of mortality. To further elucidate how bariatric surgery improves metabolic control, we explored the fatty acid (FA) profiles in morbidly obese subjects treated with lifestyle intervention and subsequent bariatric surgery.

Methods: The intervention group consisted of 34 morbidly obese patients scheduled for bariatric surgery and the control group of 17 non-obese patients scheduled for elective laparoscopic procedures. The intervention group had to undergo lifestyle changes preoperatively. Fasting blood samples were drawn at admission, after lifestyle intervention and 1 year after bariatric surgery.

Results: At admission, the morbidly obese patients had significantly higher levels of monounsaturated FAs (MUFAs) and lower levels of n-6 polyunsaturated FAs (PUFAs) and n-3 PUFAs than healthy controls (all p-values <.05). In the intervention group, there was a significantly lower level of total FAs after lifestyle intervention, and from admission to 1 year after surgical intervention (both, p < .05), primarily reflecting a lower proportion of saturated FAs (SFAs). Following bariatric surgery, but not after lifestyle changes, there was an increase in the proportion of n-3 PUFA (p < .05) reaching levels not significantly different from healthy controls.

Conclusions: Our findings suggest that a reduced proportion of the proposed anti-atherogenic n-3 PUFAs characterizes morbidly obese individuals, and that this FA profile is reversed by bariatric surgery, but not by lifestyle intervention.

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The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.

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Bariatric surgery reduces fasting total fatty acids and increases n-3 polyunsaturated fatty acids in morbidly obese individuals

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Bariatric surgery reduces fasting total fatty acids and increases n-3 polyunsaturated fatty acids in morbidly obese individuals

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