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Articles

Modulation of antioxidant enzyme gene expression by extremely low frequency electromagnetic field in post-stroke patients

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Pages 626-631 | Received 27 Apr 2018, Accepted 27 Oct 2018, Published online: 03 Jan 2019
 

Abstract

Oxidative stress plays the most important role in the pathogenesis of stroke. Extremely low frequency electromagnetic field (ELF-EMF) therapy may be complementary in post-stroke therapy, as it modulates oxidative stress. The aim of this study was to evaluate the messenger ribonucleic acid (mRNA) levels of certain antioxidant genes in post-stroke patients given ELF-EMF therapy. Forty-eight post-stroke patients were divided into two groups: an ELF-EMF group and a non-ELF-EMF group. All patients underwent the same program of physical therapy, but the ELF-EMF group was additionally given ELF-EMF treatment. In order to determine the level of gene expression, we evaluated the level of mRNA expression of catalase, superoxide dismutase, and glutathione peroxidase. We observed that after ELF-EMF therapy, the mRNA expression of the studied genes (CAT, SOD1, SOD2, GPx1, and GPx4) significantly increased, which enhanced the antioxidant defence of the body. ELF-EMF therapy intensifies the endogenous antioxidant system by increasing the mRNA expression of genes encoding antioxidant enzymes and enhances the effectiveness of post-stroke patient therapy.

Additional information

Funding

This study was supported by the Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz under Grant No. 506/1136 and Laboratory of Medical Genetics, Faculty of Biology and Environmental Protection, University of Lodz under Grant No. B161100000004601.

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