Circulating levels of inflammatory parameters pentraxin-3, cyclophilin and heparin-binding epidermal growth factor-like growth factor in patients with ST-elevation myocardial infarction

Abstract

Inflammatory biomarkers – pentraxin-3 (PTX3), cyclophilin A (CypA) and heparin-binding epidermal growth factor-like growth factor (HB-EGF) were examined in patients with ST-segment elevation myocardial infarction (STEMI) undergoing revascularization with primary percutaneous coronary intervention (pPCI) and stent implanting. Investigated parameters were compared between patients with and without obstructive coronary artery disease (CAD). In addition, their changes were tested in circulation before and immediately after pPCI. The study group consisted of 81 STEMI patients. Patients were classified in the STEMI-CAD group if they had significant obstructive CAD or in MINOCA group if they had no significant stenosis. In STEMI-CAD patients inflammatory parameters were determined prior to and after pPCI intervention. Immediately after pPCI, in STEMI-CAD patients levels of PTX3 were significantly lower (1.52 vs. 2.17 μg/L, p < .001), while the levels of HB-EGF (14.61 vs. 12.03 pg/L, p < .001) and CyPA (15.95 vs. 8.62 μg/L, p < .001) were significantly higher compared to levels before pPCI. STEMI–CAD patients had lower PTX3 values 2.17 μg/L (1.55–5.10 μg/L) than MINOCA patients 5.06 μg/L (2.77–6.7 μg/L), p = .046. Diagnostic accuracy of PTX3 for discrimination MINOCA from STEMI-CAD patients was low (area under receiver operating characteristic curve = 0.770). Evaluation of PTX3 values may be helpful in the understanding of MINOCA aetiology but they couldn’t distinguish stenosis severity in STEMI patients. Inflammatory biomarkers significantly changed after pPCI but the possibility of clinical use of these biomarkers needs to be evaluated in a larger prospective study.

Keywords:

• Pentraxin-3
• cyclophilin A
• heparin-binding epidermal growth factor – like growth factor
• ST- segment elevation myocardial infarction
• MINOCA

Author contributions

VVD performed the analysis, processed the experimental data and wrote the article. NBS designed and directed the project, edited of manuscript. JKS and VSK were involved in planning and supervising of the experiment. MZ and AN aided in interpreting the results and edited the manuscript. LM and AS performed the measurements. SK and AV were involved in planning the project and contributed to sample preparation. II, SH, MC and MS aided in interpreting the results.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was granted by the Ministry of Education, Science and Technological Development, Republic of Serbia [Project No. 175035].