Relationship between thiol, disulphide volume and contrast-induced nephropathy in acute coronary syndrome patients treated with percutaneous coronary intervention

Abstract

Background

This study aimed to evaluate thiol disulphide volume for the risk of contrast-induced nephropathy (CIN) in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI).

Methods

A total of 638 patients with ACS were enrolled in the study. CIN was defined as an increase in serum creatinine level of ≥0.5 mg/dL or ≥25% above baseline within 72 h after the procedure. Patients were divided into two groups: patients with and without CIN. Demographics, clinical risk factors, angiographic and laboratory parameters, CIN incidence, thiol, disulphide, and CHA2DS2-VASc score were compared between the two groups.

Results

Native thiol, total thiol, and disulphide at baseline were significantly lower in patients who developed CIN compared to those who did not. Also, the CHA2DS2-VASc score was found to be higher in patients with CIN than those without CIN. In receiver operating characteristic analysis showed that at a cutoff of <342.1, the value of native thiol exhibited 82% sensitivity and 80% specificity for detecting CIN. Total thiol< 383.1 calculated on admission had an 80% sensitivity and 80% specificity in predicting CIN.

Conclusion

Our study suggested that the thiol disulphide volume on admission was independently associated with the development of CIN after PCI in patients with ACS.

Keywords:

• ACS
• CIN
• disulfide
• thiol
• CHA2DS2-VASc

Disclosure statement

None of the authors declare any competing interests.

Author contributions

Study concept and design: DE, YY, SK, MTI Literature research and clinical advice: DE, SK, ZC, RY, JS, OE Acquisition, analysis, or interpretation of data:DE,SK,RY,JS, SN Drafting of the manuscript: DE, YY, ZC, MTI Critical revision of the manuscript for important intellectual content: DE, JS,RY,OE Statistical analyses: DE,ZC Study supervision: MTI All authors read and approved the final manuscript.