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Abstract
Physiological changes in hemostasis during pregnancy have been reported by several authors. This study aimed at establishing reference intervals for the hemostasis biomarkers thrombin-antithrombin complex (TAT), α2-plasmininhibitor-plasmin complex (PIC), thrombomodulin (TM) and tissue plasminogen activator-inhibitor complex (tPAI-C), in healthy pregnancies. After excluding outliers, a total of 496 healthy pregnant women (128 first-trimester, 142 second-trimester, 107 third-trimester and 119 pre-labor) and 103 healthy nonpregnant women were enrolled from Shenzhen Bao’an Women’s and Children’s Hospital. Hemostasis biomarkers, TAT, PIC, TM and tPAI-C, were measured by using a quantitative chemiluminescence enzyme immunoassay performed on HISCL automated analysers. The median and reference intervals (the 2.5th and 97.5th percentiles) were calculated to establish trimester-specific reference intervals for healthy pregnant women. The reference intervals for TAT, PIC, TM and tPAI-C in the first trimester were 0.7–7.6 1 µg/L, 0.2–0.9 mg/L, 2.8–11.0 TU/ml, and 1.2–6.5 1 µg/L, respectively. The reference intervals in the second trimester were 1.7–12.0 1 µg/L, 0.2–1.0 mg/L, 3.7–11.6 TU/ml, and 2.8–8.8 1 µg/L, respectively. The reference intervals in the third trimester were 2.7–16.1 1 µg/L, 0.1–1.4 mg/L, 2.9–12.9 TU/ml, and 1.9–8.0 1 µg/L, respectively. At pre–labor, the reference intervals were 4.8–32.9 1 µg/L, 0.2–1.9 mg/L, 4.2–12.6 TU/ml, and 2.8–15.4 1 µg/L, respectively. Gestational reference intervals for TAT, PIC, TM and tPAI-C in healthy pregnancies are provided, but only for TAT with increasing concentrations throughout pregnancy, the reference intervals for non-pregnant were not applicable.
Disclosure statement
No potential conflicts of interest are reported by the authors.