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Abstract
A case of phaeochromocytoma is described in which X-ray investigation and pharmacodynamical tests with tetraethyl-ammonium and Regitin were non-informative. The diagnosis was established by the increased excretion of catechols with the urine (1010–2400 μg noradrenaline and 16–19 μg adrenaline per 24-hour period).
Estimation of catechols in samples of the blood and of the urine from the same period showed an average blood level of 3.6 μg/100 ml noradrenaline and a corresponding urinary output of 110 μg per hour.
The high systolic and diastolic blood pressure, the electrocardiographic changes, the increased basal metabolic rate, the response to the glucose tolerance test, sweating, eosinopenia and fatigue are explained as symptoms and signs of hypernoradrenalinemia.
Biological estimation of the catechols in the tumor, which weighed 40 g, showed 590 μg/g noradrenaline and 12 μg/g adrenaline.
After operation the blood pressure and the level of the urinary catechols returned to normal.