Investigation of Viscosity and Hyaluronidase Inhibitors in Joint Exudate after Intraarticular Cortisone Injections

B. Ekman Institute of Physiological Chemistry, Department of Rheumatic Diseases, Sweden; Department of Internal Medicine, University of Lund, Sweden

S. Thune Institute of Physiological Chemistry, Department of Rheumatic Diseases, Sweden; Department of Internal Medicine, University of Lund, Sweden

E. Truedsson Institute of Physiological Chemistry, Department of Rheumatic Diseases, Sweden; Department of Internal Medicine, University of Lund, Sweden

Abstract

In joints with exudate in rheumatoid arthritis, intraarticular cortisone injection acts locally and is followed by:

1) a reduction of exudation probably due to a decrease of the permeability of the synovial membrane

2) an increase of the viscosity induced by hyaluronic acid

3) an increase of the activity of hyalu-ronidase inhibitors which may result in a decrease of the depolymerisation of hyaluronic acid.

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Investigation of Viscosity and Hyaluronidase Inhibitors in Joint Exudate after Intraarticular Cortisone Injections

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Investigation of Viscosity and Hyaluronidase Inhibitors in Joint Exudate after Intraarticular Cortisone Injections

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