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Abstract
Plasma samples from 35 patients with various diseases were investigated as to antihemophilic A factor (AHA), antihemophilic C factor (AHC) and fibrinogen. A distinct positive correlation was found between AHA and fibrinogen values. No such correlation was seen for AHC.
Three normal persons were given typhoidparatyphoid vaccine injections to induce fever and stimulation of the reticulo-endothelial system (R.E.S.). The rise in body temperature was followed by a marked temporary increase in AHA and fibrinogen. The highest values for the both factors were found on the second day after the stimulation. Proaccelerin also showed a marked rise, but this was measured one day later than for AHA and fibrinogen.
The results are consistent with the hypothesis that AHA and fibrinogen are synthesized by the same cell system, probably by the R.E.S., and that the formation rates of the two factors are closely linked.