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Scandinavian Journal of Clinical and Laboratory Investigation Volume 20, 1967 - Issue 1
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Original Article

Rate of Haptoglobin in Synthesis in Normal Man Determinations by the return to normal levels following hemoglobin infusion

W. D. Noyes Department of Medicine, University of Florida College of Medicine, Gainesville, Florida
&
L. Garby Department of Medicine, University of Florida College of Medicine, Gainesville, Florida; Visiting Research Professor, University of Florida, from the Swedish Medical Research Council Unit for Pediatric Hematology, University of Uppsala, Uppsala, Sweden
Pages 33-38 | Received 04 Mar 1967, Published online: 28 Aug 2009
 
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Abstract

Following depletion of plasma haptoglobin by formation of a complex with hemoglobin, the return to normal levels was observed and analyzed kinetically. The daily synthetic rate approximated 30–50 per cent of the intravascular pool. More than half of this daily synthesis is consumed in association with the normal metabolism of plasma hemoglobin while some other catabolic mechanism(s) is responsible for the remainder.

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