Renal Function during Prolonged Exposure to Hypoxia and Carbon Monoxide

Abstract

Studies of renal electrolyte handling under conditions of prolonged hypoxia indicate an increase in sodium and chloride elimination due to elevated tubular rejection of these electrolytes, mainly during the first 24 hours after arrival at altitude, while potassium elimination appears to be affected in a converse manner. Renal tubular electrolyte handling values in the initial phase of prolonged exposure to CO were consistent with a regulatory response to primary elevation of GFR.

Key-words:

• Kidney function tests
• diuresis
• hypoxia
• high altitude
• carbon monoxide
• sodium
• chloride
• potassium