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Abstract
Male and female mice, guinea-pigs and rabbits were studied concerning urinary excretion of histamine, urinary excretion of radioactive histamine after a subcutaneous injection of radioactive histamine and inactivation of radioactive histamine in kidney tissue in vitro. In male and female mice the urinary excretion of radioactive histamine after a subcutaneous injection of radioactive histidine was also investigated.
There was no obvious sex difference in the urinary excretion of histamine in guinea-pigs and in rabbits. In mice the urinary excretion of histamine was significantly larger in females than in males. The difference depended on a higher rate of histamine formation in females as shown by measurements of the urinary excretion of radioactive histamine after a subcutaneous injection of radioactive histidine. The percentage urinary excretion of radioactive histamine after a subcutaneous injection of radioactive histamine was about the same in both sexes in mice, guinea-pigs and rabbits, but varied between the species. There was no obvious sex difference in the inactivation of radioactive histamine in vitro in kidney slices from mice, guinea-pigs and rabbits.