Reduction in Cold-Induced Natriuresis Following Hyperoncotic Albumin Infusion in Man Undergoing Water Diuresis

Abstract

Changes in cold-induced sodium excretion following intravenous infusion of hyperoncotic human albumin solution were studied in healthy volunteers undergoing stable water diuresis and exposed to cold of +15 °C for 1 hr. A significant relationship between urinary sodium excretion and cold-induced rise in arterial blood pressure was found in the control group but could no longer be demonstrated in the albumin-infused group. Cold-induced suppression of distal tubular sodium reabsorption was almost completely abolished by an albumin infusion of 0.4 to 0.5 g per kg. The results indicate that tubular sodium reabsorption in cold-exposed man is influenced by plasma oncotic pressure and changes in arterial blood pressure.

Key Words:

• Albumin
• blood pressure
• cold
• oncotic pressure
• sodium excretion