Efflux of Prostaglandins in Right Lymphatic Duct Lymph Following Induced Intravascular Coagulation and Inhibited Fibrinolysis in the Dog

Abstract

Intravascular coagulation and inhibited fibrinolysis were induced in 10 dogs by infusion of thrombin and tranexamic acid (AMCA). Lymph fluid from the right lymphatic duct, draining the main parts of the lungs, was examined for the presence of smooth-muscle-stimulating activity. The treatment was followed by increased lymph flow due to interstitial pulmonary oedema and efflux of smooth-muscle-stimulating material. The presence of prostaglandin E₁ and E₂ (PGE₁ and E₂) and prostaglandin F-compounds as well as ‘slow reacting substance’ (SRS) in the lymph fluid was demonstrated by bioassay in combination with chromatography. Histamine was not detected in the lymph fluid.

Key Words:

• Antifibrinolytic agents
• blood coagulation disorders
• dogs
• lung lymph
• prostaglandins
• pulmonary oedema
• thrombin